Amino acids play a crucial role in brain function and neurotransmitter balance, influencing everything from mood to cognitive performance. One of the most important amino acids in this regard is L-Tyrosine, along with its more bioavailable form, N-Acetyl L-Tyrosine (NALT). These compounds are precursors to essential neurotransmitters like dopamine, norepinephrine, and epinephrine—collectively known as catecholamines.
Their impact on the nervous system, mental clarity, and conditions like ADHD, Autism, and Fibromyalgia makes them a fascinating area of study.
L-Tyrosine and Its Role in Neurotransmitter Production
L-Tyrosine is a non-essential amino acid that the body synthesizes from phenylalanine, another amino acid found in protein-rich foods. Once inside the body, L-Tyrosine undergoes conversion into L-DOPA, which then leads to the production of dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). These neurotransmitters are vital for:
Cognitive function and focus
Mood regulation and motivation
Stress response and resilience
Energy production
NALT is a modified form of L-Tyrosine that is more water-soluble, potentially allowing for better absorption. Some people find NALT more effective than standard L-Tyrosine due to its improved bioavailability, though research on this is still developing.
L-Tyrosine, ADHD, and Autism
One of the most well-known applications of L-Tyrosine is its potential benefit for individuals with Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD). ADHD is characterized by dopamine dysregulation, affecting focus, motivation, and impulse control. Since L-Tyrosine is a precursor to dopamine, supplementing with it may support dopamine production and improve symptoms like:
Difficulty concentrating
Low motivation
Mental fatigue
Mood instability
While not a replacement for traditional ADHD medications, L-Tyrosine can be a useful adjunct, particularly for individuals who are sensitive to stimulant medications.
For those on the autism spectrum, dopamine and GABA (gamma-aminobutyric acid) imbalances are often observed. GABA is the brain’s primary inhibitory neurotransmitter, responsible for calming overactive nervous system activity. Tyrosine indirectly supports GABAergic function by balancing excitatory neurotransmitters and promoting a healthier neurochemical environment.
L-Tyrosine and Fibromyalgia, ME/CFS, and Long COVID
Conditions like Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Functional Neurological Disorder (FND), and Long COVID involve complex nervous system dysfunction. One of the hallmark symptoms of these conditions is internal tremors, a sensation of buzzing or vibrating within the body, often linked to overactive sympathetic nervous system activity and dysregulated neurotransmitter levels.
L-Tyrosine plays a key role in restoring neurotransmitter balance and supporting the body’s ability to handle stress. By increasing dopamine and norepinephrine levels, it may help with:
Reducing brain fog and mental fatigue
Alleviating muscle weakness and tremors
Supporting stress resilience and adrenal function
Personally, I found that L-Tyrosine, especially when combined with L-Theanine, was one of the most effective supplements for managing internal tremors associated with nervous system disorders.
L-Theanine, an amino acid found in green tea, works synergistically with L-Tyrosine by promoting relaxation through GABA modulation while still enhancing dopamine production, creating a balanced state of focused calm.
L-Tyrosine’s Role in Feel-Good Hormones and Nervous System Regulation
Beyond dopamine, L-Tyrosine is linked to several feel-good hormones and neurotransmitters, including:
Dopamine: Responsible for pleasure, motivation, and reward-seeking behaviour.
Norepinephrine & Epinephrine: Regulate alertness, energy, and the body's response to stress.
Endorphins: Play a role in pain relief and a sense of well-being.
GABA: Helps calm the nervous system, preventing overstimulation and excitotoxicity.
For individuals struggling with neurotransmitter depletion due to chronic stress, illness, or nervous system dysregulation, supplementing with L-Tyrosine may provide an essential boost to mental and physical well-being.
L-Tyrosine and the Nervous System
The nervous system relies on a delicate balance of neurotransmitters and amino acids to function optimally. L-Tyrosine is particularly important for the autonomic nervous system (ANS), which controls involuntary functions like heart rate, digestion, and stress response.
A well-balanced ANS allows for smooth transitions between the sympathetic (fight-or-flight) and parasympathetic (rest-and-digest) states.
Chronic illness, prolonged stress, and nervous system disorders can deplete neurotransmitter levels, leading to symptoms such as:
Persistent fatigue
Heightened anxiety or overactivation
Cognitive dysfunction (brain fog)
Increased pain sensitivity
Poor stress tolerance
By replenishing dopamine, norepinephrine, and GABA, L-Tyrosine supports a more resilient and adaptable nervous system, helping to restore balance and reduce hypersensitivity to stressors.
How to Use L-Tyrosine and NALT Safely
L-Tyrosine and NALT are generally well-tolerated, but dosage is key. Too much can lead to overstimulation, anxiety, or headaches. Here are some general recommendations:
Dosage: 500–2000mg per day, ideally taken on an empty stomach in the morning or before cognitive tasks.
Timing: If using for ADHD or focus, take in the morning or early afternoon. Avoid late-night use to prevent insomnia.
Stacking: Combining L-Tyrosine with L-Theanine can enhance the calming effects while still boosting dopamine levels.
Final Thoughts
L-Tyrosine and NALT are powerful amino acids with far-reaching effects on dopamine regulation, nervous system balance, and cognitive function. Whether you’re looking to enhance focus, manage ADHD, calm internal tremors, or support overall neurotransmitter health, these supplements offer a promising natural approach.
As always, it’s best to consult a healthcare provider before starting any new supplement, especially for those with pre-existing medical conditions or on medications affecting dopamine metabolism.
For those navigating conditions like Fibromyalgia, ME/CFS, Long COVID, and FND, where neurotransmitter dysfunction plays a role, targeted amino acid support may be a valuable part of the recovery journey.
L-Tyrosine for Internal Tremors, ADHD, and Fibromyalgia: A Natural Nervous System Support
References
Fernstrom, J. D. (2000). "Can Nutritional Supplements Modify Brain Function?" The American Journal of Clinical Nutrition, 71(6), 1669S-1673S.
Swanson, J. M., Baler, R. D., & Volkow, N. D. (2011). "Understanding the Effects of Dopamine on ADHD and Neurodevelopment." Trends in Neurosciences, 34(12), 611-618.
Lambert, P. D., et al. (2003). "The Role of Tyrosine in Dopaminergic Neurotransmission." Neuroscience & Biobehavioral Reviews, 27(3), 293-301.
Leigh Gibson, E. (2007). "Cognitive Performance, Sleep, and Nutrition: The Role of Tyrosine." Nutrition Bulletin, 32(2), 85-94.
Yamadera, W., et al. (2007). "L-Theanine and Its Neuroprotective Role in Modulating Stress Responses." Journal of Physiological Anthropology, 26(2), 93-98.
Nirenberg, M. J., & Waters, C. (2006). "Dopamine and Neurological Disorders: Implications for Fibromyalgia and Chronic Fatigue Syndrome." Neurology & Clinical Neuroscience, 24(2), 85-101.
Martinez, F. (2018). "Neurotransmitter Dysfunction in Fibromyalgia and ME/CFS: Role of Dopamine and GABA." Current Rheumatology Reports, 20(11), 71.
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